afatinib
Sensitive Cell Lines
afatinib (BRD:BRD-K66175015-001-12-4) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 19Q4
376 cell lines shown
AUC
Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. View more
Enriched Lineages
afatinib (BRD:BRD-K66175015-001-12-4) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 19Q4
AUC
1. Upper Aerodigestive (3.4e-05) n=22
2. Upper Aerodigestive Squamous (3.4e-05) n=22
3. Esophagus (3.6e-04) n=20
Top Correlated Expression
| Gene | Pearson correlation | |
|---|---|---|
| Plot | IRF6 | -0.52 |
| Plot | GRB7 | -0.50 |
| Plot | ARHGAP8 | -0.48 |
| Plot | LAD1 | -0.48 |
| Plot | KDF1 | -0.48 |
All viability profiles for a given compound were correlated against all expression features. The highest correlated viability profile for each gene reported in the table above. Clicking 'plot' will visualize that comparison and show which dataset was used for the viability profile.
Datasets with data for afatinib
| Dataset | Cell Lines | Dose Range | Assay |
|---|---|---|---|
| CTRP | 815 | 0.002μM - 66μM | CellTitreGlo |
| GDSC1 | 966 | 0.00195μM - 10μM | Resazurin or Syto60 |
| GDSC2 | 791 | 0.002μM - 10μM | CellTitreGlo |
| Repurposing Secondary | 480 | 0.00061μM - 10μM | PRISM |
