afatinib
Sensitive Cell Lines
afatinib (BRD:BRD-K66175015-001-09-0) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 18/11 Public Tentative
25 cell lines shown
AUC
Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. View more
Enriched Lineages
afatinib (BRD:BRD-K66175015-001-09-0) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 18/11 Public Tentative
AUC
Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.
Top Correlated Expression
| Gene | Pearson correlation | |
|---|---|---|
| Plot | GDF5OS | 0.80 |
| Plot | MYL2 | 0.77 |
| Plot | ITGAD | 0.76 |
| Plot | OLAH | 0.76 |
| Plot | VSTM1 | 0.76 |
All viability profiles for a given compound were correlated against all expression features. The highest correlated viability profile for each gene reported in the table above. Clicking 'plot' will visualize that comparison and show which dataset was used for the viability profile.
Datasets with data for afatinib
| Dataset | Cell Lines | Dose Range | Assay |
|---|---|---|---|
| Repurposing Primary | 578 | 2.5μM | PRISM |
| CTRP | 860 | 1nM - 10μM | CellTitreGlo |
| GDSC2 | 809 | 1nM - 10μM | CellTitreGlo |
| Repurposing Secondary | 489 | 1nM - 10μM | PRISM |
| GDSC1 | 987 | 1nM - 10μM | Resazurin or Syto60 |
Choose dataset
This symbol 
indicates that dose-level data is available for the dataset. Click on a point to view a dose
curve.
indicates that dose-level data is available for the dataset. Click on a point to view a dose
curve.
Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. Additionally, CTRP AUCs are not normalized by the dose range and thus have values greater than 1.