dabrafenib

Sensitive Cell Lines

dabrafenib (BRD:BRD-K09951645-001-06-8) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 19Q4

46 cell lines shown


AUC


Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. View more


Enriched Lineages

dabrafenib (BRD:BRD-K09951645-001-06-8) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 19Q4

AUC


Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.


Top Correlated Expression

GenePearson correlation
Plot USH1G 0.64
Plot KRT5 0.63
Plot CD86 0.62
Plot TRIM51 -0.62
Plot TLE1 -0.62

All viability profiles for a given compound were correlated against all expression features. The highest correlated viability profile for each gene reported in the table above. Clicking 'plot' will visualize that comparison and show which dataset was used for the viability profile.

Datasets with data for dabrafenib

DatasetCell LinesDose RangeAssay
CTRP 860 1nM - 10μM CellTitreGlo
GDSC1 987 1nM - 10μM Resazurin or Syto60
GDSC2 809 1nM - 10μM CellTitreGlo
Repurposing Primary 578 2.5μM PRISM
Repurposing Secondary 489 1nM - 10μM PRISM


Metadata from the Repurposing Hub

MOA: RAF inhibitor
Disease Area: oncology
Indication: melanoma
Phase: Launched
Target: BRAF, LIMK1, NEK11, RAF1, SIK1

Choose dataset

This symbol indicates that dose-level data is available for the dataset. Click on a point to view a dose curve.

Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. Additionally, CTRP AUCs are not normalized by the dose range and thus have values greater than 1.