nutlin-3

Sensitive Cell Lines

nutlin-3 (BRD:BRD-A12230535-001-06-7) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 18/11 Public Tentative

440 cell lines shown


AUC


Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. View more


Enriched Lineages

nutlin-3 (BRD:BRD-A12230535-001-06-7) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 18/11 Public Tentative

AUC

1. Melanoma (4.9e-04) n=39
2. Skin (4.9e-04) n=39


Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.


Top Correlated Expression

GenePearson correlation
Plot APOBEC3H -0.52
Plot LILRB4 -0.47
Plot FUT7 -0.46
Plot CAV2 0.45
Plot MET 0.45

All viability profiles for a given compound were correlated against all expression features. The highest correlated viability profile for each gene reported in the table above. Clicking 'plot' will visualize that comparison and show which dataset was used for the viability profile.

Datasets with data for nutlin-3

DatasetCell LinesDose RangeAssay
GDSC2 809 1nM - 10μM CellTitreGlo
Repurposing Secondary 489 1nM - 10μM PRISM
CTRP 860 1nM - 10μM CellTitreGlo
Repurposing Primary 578 2.5μM PRISM
GDSC1 987 1nM - 10μM Resazurin or Syto60


Metadata from the Repurposing Hub

MOA: MDM inhibitor
Phase: Preclinical
Target: MDM2, TP53

Choose dataset

This symbol indicates that dose-level data is available for the dataset. Click on a point to view a dose curve.

Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. Additionally, CTRP AUCs are not normalized by the dose range and thus have values greater than 1.