Genetic Vulnerabilities

CRISPR (Broad Avana)

The latest (2018Q2) release of 436 cell lines screened with the Avana 1.0 library.


This Achilles dataset contains the results of genome-scale CRISPR knockout screens using the GeCKO library in 33 cell lines.

RNAi (Broad Achilles)

Final RNAi dataset containing 501 cell lines that was used to support the publication Tsherniak A, Vasquez F, et al., Cell, 2017. Defining a cancer dependency map.

RNAi (Novartis DRIVE)

A RNAi dataset containing 398 cell lines generated by Novartis published in McDonald III et al., Cell, 2017. Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

RNAi (Combined Broad, Novartis, Marcotte)

An integrated RNAi dataset of gene dependencies covering a total of 713 cell lines, as described in McFarland J, et al., bioRxiv, 2018. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration.

Drug Sensitivity

Drug sensitivity (Sanger)

Wellcome Sanger Institute drug sensitivity data for 700+ cell lines

Genomic Characterizations of Cellular Models

Genomic features (CCLE)

Characterization of Expression, Copy number, fusions/translocation, RPPA, methylation etc. of 1000+ cell lines

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