AACS

acetoacetyl-CoA synthetase

Dependent Cell Lines

CRISPR: 1/625

RNAi: 2/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPRG2-0.25
PlotNEMP10.24
PlotARRDC40.23
PlotCDK2AP2-0.23
PlotINHBE0.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRNASE13-0.36
PlotTMBIM10.34
PlotTHNSL20.30
PlotOTUB10.29
PlotRBP40.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (12 125548912-125549912)

CpG Methylation

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  • Official symbol: AACS
  • Full name: acetoacetyl-CoA synthetase
  • Location:
  • Also known as: SUR-5, ACSF1, FLJ12389
  • Entrez ID: 65985
  • Ensembl ID: ENSG00000081760

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