ABHD10

abhydrolase domain containing 10

Dependent Cell Lines

CRISPR: 0/625

RNAi: 7/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Leukemia (9.0e-05)
2. Colorectal (1.1e-04)
3. Lung Adenocarcinoma (1.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Glioma (4.4e-08)
2. Glioblastoma (1.4e-07)
3. Central Nervous System (1.9e-06)
4. Haematopoietic And Lymphoid (2.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotLY960.34
PlotWDR5B0.31
PlotOCLM0.30
PlotSELENOT0.30
PlotGRAMD1C0.29

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMAF1-0.46
PlotRUBCNL0.45
PlotKRT9-0.41
PlotACER20.40
PlotFAM19A5-0.39

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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  • Official symbol: ABHD10
  • Full name: abhydrolase domain containing 10
  • Location:
  • Also known as: FLJ11342
  • Entrez ID: 55347
  • Ensembl ID: ENSG00000144827

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