ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Dependent Cell Lines

CRISPR: 6/625 STRONGLY SELECTIVE

RNAi: 3/711 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. CML (2.0e-53)
2. Leukemia (4.6e-06)

RNAi

Dependency Score (DEMETER2)

1. Leukemia (4.5e-15)
2. Haematopoietic And Lymphoid (5.0e-10)
3. AML (3.5e-08)
4. Solid (1.5e-06)
5. Thyroid (1.4e-04)
6. Kidney (2.5e-04)
7. Mesothelioma (3.5e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotBCR0.37
PlotZFPM10.28
PlotCRK-0.23
PlotQRFP0.22
PlotINPPL10.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCYLC20.38
PlotANKRD20.38
PlotPDCD100.36
PlotTAOK10.36
PlotRAC1-0.35

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for ABL1

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Translocation

Loading table...

Methylation (1kb upstream TSS) (9 133588267-133589267)

Methylation (1kb upstream TSS) (9 133709641-133710641)

CpG Methylation

Select context(s) and press load



  • Official symbol: ABL1
  • Full name: ABL proto-oncogene 1, non-receptor tyrosine kinase
  • Location:
  • Also known as: ABL, c-ABL, p150, JTK7
  • Entrez ID: 25
  • Ensembl ID: ENSG00000097007

Search external sites for ABL1