ADAR

adenosine deaminase, RNA specific

Dependent Cell Lines

CRISPR: 221/625

RNAi: 99/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (4.5e-05)
2. Esophagus (6.6e-05)
3. Upper Aerodigestive Squamous (8.3e-05)
4. Esophagus Squamous (2.8e-04)

RNAi

Dependency Score (DEMETER2)

1. Esophagus (1.6e-04)
2. Upper Aerodigestive (3.7e-04)
3. Upper Aerodigestive Squamous (3.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotXRN10.43
PlotPRKRA0.33
PlotSTAT2-0.29
PlotIRF9-0.29
PlotIFNAR2-0.29

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPRKRA0.42
PlotKLK20.32
PlotIST10.31
PlotC5orf520.30
PlotHMGXB30.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (1 154600473-154601473)

Methylation (1kb upstream TSS) (1 154580662-154581662)

Methylation (1kb upstream TSS) (1 154600447-154601447)

CpG Methylation

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  • Official symbol: ADAR
  • Full name: adenosine deaminase, RNA specific
  • Location:
  • Also known as: G1P1, IFI4, ADAR1
  • Entrez ID: 103
  • Ensembl ID: ENSG00000160710

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