AFF1

AF4/FMR2 family member 1

Dependent Cell Lines

CRISPR: 0/625

RNAi: 7/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (4.3e-13)
2. Solid (1.0e-12)
3. Multiple Myeloma (1.6e-12)
4. Leukemia (1.4e-06)
5. AML (1.1e-05)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (6.5e-26)
2. Solid (1.8e-20)
3. Leukemia (4.7e-16)
4. Multiple Myeloma (2.0e-15)
5. AML (2.4e-11)
6. B-cell ALL (6.0e-07)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotMED13L0.33
PlotARHGAP450.30
PlotELL20.30
PlotMEF2C0.29
PlotFLI10.27

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotLDAH0.41
PlotLDAH0.41
PlotWDFY40.38
PlotSTXBP5L0.36
PlotWIPI20.36

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (4 87927139-87928139)

Methylation (1kb upstream TSS) (4 87855153-87856153)

CpG Methylation

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  • Official symbol: AFF1
  • Full name: AF4/FMR2 family member 1
  • Location:
  • Also known as: AF4, PBM1, AF-4, MLLT2
  • Entrez ID: 4299
  • Ensembl ID: ENSG00000172493

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