ATP6V1B2

ATPase H+ transporting V1 subunit B2

Dependent Cell Lines

CRISPR: 621/625 COMMON ESSENTIAL

RNAi: 288/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. ERpos (4.3e-09)
2. Melanoma (2.4e-07)
3. Haematopoietic And Lymphoid (5.9e-05)
4. Skin (6.0e-05)
5. Solid (6.7e-05)
6. Breast (4.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Lung Adenocarcinoma (2.5e-05)
2. Upper Aerodigestive (8.5e-05)
3. Upper Aerodigestive Squamous (8.5e-05)
4. AML (1.7e-04)
5. Pancreas (1.9e-04)
6. Leukemia (2.3e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotATP6V0C0.47
PlotATP6V1A0.45
PlotATP6V1F0.41
PlotATP6V0B0.34
PlotATP6V1E10.32

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotWDR70.50
PlotATP6V1A0.41
PlotATP6V0C0.41
PlotATP6AP10.38
PlotATP6V0B0.35

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (8 20053703-20054703)

CpG Methylation

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  • Official symbol: ATP6V1B2
  • Full name: ATPase H+ transporting V1 subunit B2
  • Location:
  • Also known as: Vma2, VATB, ATP6B2, VPP3, HO57
  • Entrez ID: 526
  • Ensembl ID: ENSG00000147416

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