ATRN

attractin

Dependent Cell Lines

CRISPR: 20/625

RNAi: 0/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (2.1e-04)
2. Upper Aerodigestive Squamous (2.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Glioma (1.4e-04)
2. Glioblastoma (1.8e-04)
3. Haematopoietic And Lymphoid (2.0e-04)
4. Leukemia (3.5e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotMGRN10.48
PlotITGAV0.36
PlotELMO20.34
PlotPTK20.33
PlotARHGEF120.30

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMAF1-0.30
PlotBTBD19-0.29
PlotTHAP1-0.29
PlotPTPN6-0.27
PlotSTRN4-0.27

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (20 3450664-3451664)

CpG Methylation

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  • Official symbol: ATRN
  • Full name: attractin
  • Location:
  • Also known as: DPPT-L, MGCA
  • Entrez ID: 8455
  • Ensembl ID: ENSG00000088812

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