B4GALT4

beta-1,4-galactosyltransferase 4

Dependent Cell Lines

CRISPR: 0/625

RNAi: 46/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotC3orf520.32
PlotTPRA10.30
PlotKPNA10.27
PlotZNF2660.27
PlotWDR630.27

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotISG200.38
PlotEXOC60.31
PlotHSPB70.30
PlotPRSS350.30
PlotEIF4A30.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (3 118959752-118960752)

CpG Methylation

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  • Official symbol: B4GALT4
  • Full name: beta-1,4-galactosyltransferase 4
  • Location:
  • Also known as: beta4Gal-T4
  • Entrez ID: 8702
  • Ensembl ID: ENSG00000121578

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