BCO1

beta-carotene oxygenase 1

Dependent Cell Lines

CRISPR: 1/625

RNAi: 39/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Lung Large (1.4e-05)
2. Lung NSC (2.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotADPRHL10.25
PlotHSDL10.23
PlotABHD130.23
PlotMAGED10.21
PlotNUDT140.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotN6AMT10.42
PlotPRPF38A0.34
PlotC5AR20.34
PlotTP53I11-0.32
PlotSH3D19-0.30

Target Tractability



Description

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Fusion 19Q3

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  • Official symbol: BCO1
  • Full name: beta-carotene oxygenase 1
  • Location:
  • Also known as: BCMO1, BCDO1, BCDO, BCMO, FLJ10730
  • Entrez ID: 53630
  • Ensembl ID: ENSG00000135697

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