BUD31

BUD31 homolog

Dependent Cell Lines

CRISPR: 624/625 COMMON ESSENTIAL

RNAi: 536/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. AML (3.8e-04)

RNAi

Dependency Score (DEMETER2)

1. Skin (9.7e-07)
2. Melanoma (1.7e-06)
3. Leukemia (3.8e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSLU70.32
PlotSF3A10.31
PlotSNRNP2000.31
PlotSARS0.31
PlotCDC5L0.31

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMCM70.35
PlotSEM10.34
PlotCOPS60.34
PlotPSMC20.32
PlotNIP70.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (7 99005600-99006600)

CpG Methylation

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  • Official symbol: BUD31
  • Full name: BUD31 homolog
  • Location:
  • Also known as: EDG2, fSAP17, Cwc14, YCR063W, EDG-2, G10
  • Entrez ID: 8896
  • Ensembl ID: ENSG00000106245

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