CBFB

core-binding factor subunit beta

Dependent Cell Lines

CRISPR: 136/625

RNAi: 22/670 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (8.0e-43)
2. Solid (2.8e-42)
3. Leukemia (3.4e-27)
4. AML (1.1e-16)
5. Multiple Myeloma (7.2e-13)
6. B-cell ALL (8.2e-06)
7. CML (5.0e-04)

RNAi

Dependency Score (DEMETER2)

1. Leukemia (1.2e-77)
2. AML (1.8e-64)
3. Haematopoietic And Lymphoid (5.8e-56)
4. Solid (1.2e-52)
5. B-cell ALL (6.7e-10)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRUNX10.63
PlotMYB0.44
PlotRUNX20.38
PlotARHGAP450.37
PlotBCL20.33

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRUNX10.60
PlotMYB0.52
PlotFLI10.39
PlotLMO20.35
PlotRANBP170.34

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (16 67062049-67063049)

CpG Methylation

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  • Official symbol: CBFB
  • Full name: core-binding factor subunit beta
  • Location:
  • Also known as: PEBP2B
  • Entrez ID: 865
  • Ensembl ID: ENSG00000067955

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