CCDC71

coiled-coil domain containing 71

Dependent Cell Lines

CRISPR: 1/625

RNAi: 2/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPFKFB40.25
PlotBSN0.25
PlotGNAT10.24
PlotSTIMATE0.23
PlotNT5DC20.23

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotGCM20.30
PlotGCM20.30
PlotGPR330.28
PlotTBC1D30-0.26
PlotWDR38-0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (3 49203785-49204785)

CpG Methylation

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  • Official symbol: CCDC71
  • Full name: coiled-coil domain containing 71
  • Location:
  • Also known as: FLJ12800
  • Entrez ID: 64925
  • Ensembl ID: ENSG00000177352

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