CCND1

cyclin D1

Dependent Cell Lines

CRISPR: 501/625 COMMON ESSENTIAL

RNAi: 174/712

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Solid (7.4e-13)
2. Haematopoietic And Lymphoid (1.5e-12)
3. Neuroblastoma (3.0e-09)
4. Peripheral Nervous System (3.0e-09)
5. Leukemia (4.2e-07)
6. Melanoma (1.1e-06)
7. Skin (1.0e-05)
8. AML (1.2e-05)
9. Lymphoma (1.5e-05)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (5.5e-11)
2. Solid (4.5e-10)
3. Neuroblastoma (8.3e-10)
4. Peripheral Nervous System (8.3e-10)
5. Leukemia (2.0e-07)
6. ERpos (2.4e-05)
7. AML (4.7e-05)
8. Lymphoma (6.3e-05)
9. Melanoma (7.0e-05)
10. Skin (1.5e-04)
11. Lung Small (4.3e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCDK40.41
PlotDYRK1A-0.31
PlotCCND2-0.26
PlotRBL10.26
PlotMRGPRD0.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCDK40.51
PlotC3orf300.46
PlotDRAM10.44
PlotPDC0.44
PlotHAP10.39

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (11 69454872-69455872)

CpG Methylation

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  • Official symbol: CCND1
  • Full name: cyclin D1
  • Location:
  • Also known as: BCL1, U21B31, D11S287E, PRAD1
  • Entrez ID: 595
  • Ensembl ID: ENSG00000110092

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