CDK4

cyclin dependent kinase 4

Dependent Cell Lines

CRISPR: 306/625 STRONGLY SELECTIVE

RNAi: 86/712 STRONGLY SELECTIVE

Dependency Score

Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. ERpos (1.3e-08)
2. Ewing Sarcoma (4.8e-07)
3. Breast (3.1e-06)
4. Melanoma (3.9e-05)
5. Bone (7.9e-05)

RNAi

Dependency Score (DEMETER2)

1. ERpos (1.3e-07)
2. Breast (2.8e-05)
3. Ewing Sarcoma (3.4e-05)
4. Bone (2.3e-04)

Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCCND10.41
PlotCDKN2C-0.31
PlotRB1-0.27
PlotFOXA10.27
PlotNIPBL0.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCCND10.51
PlotSH3D190.44
PlotSH3D190.44
PlotLINC004870.32
PlotFOXA10.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (12 58146230-58147230)

CpG Methylation

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  • Official symbol: CDK4
  • Full name: cyclin dependent kinase 4
  • Location:
  • Also known as: PSK-J3
  • Entrez ID: 1019
  • Ensembl ID: ENSG00000135446

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