CEPT1

choline/ethanolamine phosphotransferase 1

Dependent Cell Lines

CRISPR: 126/625 STRONGLY SELECTIVE

RNAi: 5/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Lymphoma (5.8e-07)
2. Melanoma (8.8e-06)
3. Upper Aerodigestive (2.1e-05)
4. Upper Aerodigestive Squamous (2.6e-05)
5. Skin (4.8e-04)
6. DLBCL (4.8e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotITSN20.23
PlotRAB3GAP20.21
PlotMEF2B0.21
PlotVPS540.20
PlotEPS15L10.19

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSRRM50.37
PlotTMPRSS11BNL0.36
PlotTMEM2330.35
PlotMYO60.34
PlotOR1J40.33

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (1 111681784-111682784)

Methylation (1kb upstream TSS) (1 111681442-111682442)

CpG Methylation

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  • Official symbol: CEPT1
  • Full name: choline/ethanolamine phosphotransferase 1
  • Location:
  • Also known as:
  • Entrez ID: 10390
  • Ensembl ID: ENSG00000134255

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