CFLAR

CASP8 and FADD like apoptosis regulator

Dependent Cell Lines

CRISPR: 381/625

RNAi: 64/708

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Kidney (1.4e-08)
2. Multiple Myeloma (3.5e-08)
3. Central Nervous System (2.8e-05)
4. Glioma (6.3e-05)
5. Melanoma (1.5e-04)
6. Bone (2.1e-04)
7. Haematopoietic And Lymphoid (2.3e-04)
8. Glioblastoma (2.8e-04)
9. Skin (3.0e-04)
10. Pancreas (4.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Multiple Myeloma (5.7e-07)
2. Kidney (1.5e-05)
3. Central Nervous System (2.3e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotZNF6380.46
PlotNCOA50.40
PlotATP6V1G10.37
PlotFADD0.36
PlotRNF310.36

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotZNF6380.47
PlotCASP8-0.36
PlotRELA0.35
PlotRETN0.29
PlotGLB1L20.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (2 201982213-201983213)

Methylation (1kb upstream TSS) (2 202003997-202004997)

CpG Methylation

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  • Official symbol: CFLAR
  • Full name: CASP8 and FADD like apoptosis regulator
  • Location:
  • Also known as: FLIP, FLAME, Casper, c-FLIP, CASH, CASP8AP1, CLARP, I-FLICE, MRIT
  • Entrez ID: 8837
  • Ensembl ID: ENSG00000003402

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