CIAO2B
cytosolic iron-sulfur assembly component 2B
Dependent Cell Lines
CRISPR: 787/789 COMMON ESSENTIAL
RNAi: 19/343
Gene Effect
Dependent Cell Line:
A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Probability of Dependency:
Probabilities of dependency are calculated for each gene score in a cell line as the probability that score arises from the distribution of essential gene scores rather than nonessential gene scores. See here for details.
Common Essential:
A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.
Enriched Lineages
CRISPR
Gene Effect (CERES)
1. Bone (4.1e-05) n=29
RNAi
Gene Effect (DEMETER2)
Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.
Expression & CN
Expression
Copy Number log2(relative to ploidy + 1)
Expression:
RNASeq files are aligned with STAR and quantified with RSEM, then TPM-normalized. Reported values are log2(TPM+1).
Copy Number:
The relative copy number pipeline used varies by cell line. For around 1000 lines, Sanger WES data was used, while for around 700 lines, Broad WES data was used. The remaining lines use SNP array data as explained in 10.1038/s41586-019-1186-3. See 10.1101/720243 for details on how CN source is chosen per line. Lines with WES data were processed through GATK using PONs from TCGA without matched normals and transformed by log2(x+1).
Target Tractability
Description
Expression Public 20Q3
Copy Number (Absolute)
Copy Number Public 20Q3
Mutation Public 20Q3
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Methylation (1kb upstream TSS) (16 66968326-66969326)
CpG Methylation
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Proteomics (Q9Y3D0)
- Official symbol: CIAO2B
- Full name: cytosolic iron-sulfur assembly component 2B
- Location:
- Also known as: CGI-128, CIA2B, FAM96B, MIP18
- Entrez ID: 51647
- Ensembl ID: ENSG00000166595
Search external sites for CIAO2B
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