CKMT1B

creatine kinase, mitochondrial 1B

Dependent Cell Lines

CRISPR: 0/625

RNAi: 65/708

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. AML (5.9e-05)
2. Bone (3.0e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSTRC0.39
PlotGOLGA8B0.32
PlotPPP1R14D0.32
PlotNUSAP10.30
PlotGPR1760.29

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCKMT1A-0.61
PlotARHGAP27P1-BPTFP1-KPNA2P30.30
PlotARHGAP27P1-BPTFP1-KPNA2P30.30
PlotRPS180.29
PlotRNASE130.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: CKMT1B
  • Full name: creatine kinase, mitochondrial 1B
  • Location:
  • Also known as: CKMT1, UMTCK, CKMT
  • Entrez ID: 1159
  • Ensembl ID: ENSG00000237289

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