CLSPN

claspin

Dependent Cell Lines

CRISPR: 488/625 COMMON ESSENTIAL

RNAi: 421/600

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Neuroblastoma (1.9e-04)
2. Peripheral Nervous System (1.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Neuroblastoma (3.4e-04)
2. Peripheral Nervous System (3.4e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotECD0.24
PlotTRAPPC30.23
PlotCCL3L3-0.22
PlotSTMP10.22
PlotSRP14-0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPOLE0.35
PlotWEE10.33
PlotCHEK10.31
PlotTIMELESS0.30
PlotRRM20.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (1 36235551-36236551)

CpG Methylation

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  • Official symbol: CLSPN
  • Full name: claspin
  • Location:
  • Also known as:
  • Entrez ID: 63967
  • Ensembl ID: ENSG00000092853

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