CMPK1

cytidine/uridine monophosphate kinase 1

Dependent Cell Lines

CRISPR: 605/625 COMMON ESSENTIAL

RNAi: 196/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Glioma (1.9e-09)
2. Central Nervous System (2.2e-09)
3. Glioblastoma (4.1e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotDTYMK0.39
PlotYRDC0.38
PlotGMPS0.33
PlotMAT2A0.30
PlotMVD0.30

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTP53I11-0.29
PlotVPS250.27
PlotVARS20.26
PlotONECUT3-0.25
PlotGATAD1-0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: CMPK1
  • Full name: cytidine/uridine monophosphate kinase 1
  • Location:
  • Also known as: CMPK, UMP-CMPK
  • Entrez ID: 51727
  • Ensembl ID: ENSG00000162368

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