COPZ1

coatomer protein complex subunit zeta 1

Dependent Cell Lines

CRISPR: 620/625 COMMON ESSENTIAL

RNAi: 637/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (1.8e-07)
2. Solid (2.5e-07)
3. AML (2.3e-06)
4. Multiple Myeloma (8.7e-05)

RNAi

Dependency Score (DEMETER2)

1. Colorectal (7.0e-05)
2. Liver (4.1e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPSMC10.33
PlotCOPB20.33
PlotCOPA0.32
PlotPSMA20.31
PlotNUDT210.31

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCOPB20.42
PlotCOPA0.41
PlotCOPG10.35
PlotF10-0.28
PlotNSF0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (12 54717873-54718873)

CpG Methylation

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  • Official symbol: COPZ1
  • Full name: coatomer protein complex subunit zeta 1
  • Location:
  • Also known as: CGI-120, COPZ
  • Entrez ID: 22818
  • Ensembl ID: ENSG00000111481

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