COQ6

coenzyme Q6, monooxygenase

Dependent Cell Lines

CRISPR: 46/625

RNAi: 2/501

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (5.2e-06)
2. Solid (5.2e-06)
3. Multiple Myeloma (6.5e-06)
4. Bone (1.5e-05)
5. Ewing Sarcoma (6.6e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCOQ70.41
PlotCOA70.39
PlotCARS20.38
PlotMTG10.37
PlotNDUFAF70.37

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotARMH4-0.46
PlotARMH4-0.46
PlotLDAH-0.33
PlotLDAH-0.33
PlotSLC10A40.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (14 74415954-74416954)

Methylation (1kb upstream TSS) (14 74415636-74416636)

CpG Methylation

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  • Official symbol: COQ6
  • Full name: coenzyme Q6, monooxygenase
  • Location:
  • Also known as: CGI-10
  • Entrez ID: 51004
  • Ensembl ID: ENSG00000119723

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