CTBP1

C-terminal binding protein 1

Dependent Cell Lines

CRISPR: 6/625

RNAi: 6/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Multiple Myeloma (2.5e-13)
2. Solid (9.9e-11)
3. Haematopoietic And Lymphoid (1.8e-10)
4. Leukemia (6.2e-05)

RNAi

Dependency Score (DEMETER2)

1. Lung Small (2.2e-05)
2. Lung (2.1e-04)
3. Multiple Myeloma (4.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCTBP20.33
PlotTCF30.28
PlotZEB10.28
PlotZNF2170.26
PlotBRD90.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotWDFY40.31
PlotIQCF5-0.31
PlotOR4D2-0.29
PlotPDCD10-0.29
PlotRPN20.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (4 1242908-1243908)

CpG Methylation

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  • Official symbol: CTBP1
  • Full name: C-terminal binding protein 1
  • Location:
  • Also known as: BARS
  • Entrez ID: 1487
  • Ensembl ID: ENSG00000159692

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