CTPS1

CTP synthase 1

Dependent Cell Lines

CRISPR: 488/625 COMMON ESSENTIAL

RNAi: 0/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (1.2e-12)
2. Solid (4.0e-12)
3. Leukemia (3.3e-11)
4. Glioma (1.1e-06)
5. Central Nervous System (2.9e-06)
6. Bone (4.6e-05)
7. AML (9.0e-05)

RNAi

Dependency Score (DEMETER2)

1. Mesothelioma (1.6e-04)
2. Lung Adenocarcinoma (2.6e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCAD0.60
PlotUMPS0.58
PlotPAICS0.54
PlotADSL0.53
PlotDHODH0.52

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTIMELESS0.27
PlotLSG10.27
PlotDET10.25
PlotMYO7B-0.25
PlotSBDS0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (1 41443970-41444970)

Methylation (1kb upstream TSS) (1 41444367-41445367)

CpG Methylation

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  • Official symbol: CTPS1
  • Full name: CTP synthase 1
  • Location:
  • Also known as: GATD5, CTPS
  • Entrez ID: 1503
  • Ensembl ID: ENSG00000171793

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