CYC1

cytochrome c1

Dependent Cell Lines

CRISPR: 570/625 COMMON ESSENTIAL

RNAi: 65/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Central Nervous System (1.5e-04)

RNAi

Dependency Score (DEMETER2)

1. Kidney (4.7e-05)
2. Glioma (2.3e-04)
3. Central Nervous System (4.3e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotUQCRC20.74
PlotCOX4I10.72
PlotUQCRC10.71
PlotNDUFB100.69
PlotCOA60.68

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotNDUFS70.50
PlotMRPL380.50
PlotMRPS150.49
PlotATP5F1A0.47
PlotPNPT10.46

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (8 145148937-145149937)

CpG Methylation

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  • Official symbol: CYC1
  • Full name: cytochrome c1
  • Location:
  • Also known as: UQCR4
  • Entrez ID: 1537
  • Ensembl ID: ENSG00000179091

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