DDX21

DExD-box helicase 21

Dependent Cell Lines

CRISPR: 569/625 COMMON ESSENTIAL

RNAi: 459/710 COMMON ESSENTIAL

Dependency Score

Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (3.6e-07)
2. Skin (2.1e-06)
3. Haematopoietic And Lymphoid (8.9e-06)
4. Solid (1.9e-05)
5. Leukemia (3.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (3.3e-06)
2. Melanoma (1.3e-05)
3. Solid (4.7e-05)
4. Leukemia (5.4e-05)
5. Skin (5.9e-05)
6. TNBC (3.4e-04)

Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNCL0.46
PlotHSPA140.45
PlotC19orf530.33
PlotZNHIT30.32
PlotCDKN1A-0.32

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotDDX100.50
PlotNCL0.49
PlotWDR360.44
PlotWDR30.44
PlotWDR460.44

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (10 70715195-70716195)

CpG Methylation

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  • Official symbol: DDX21
  • Full name: DExD-box helicase 21
  • Location:
  • Also known as: RH-II/GU, GURDB
  • Entrez ID: 9188
  • Ensembl ID: ENSG00000165732

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