DLST

dihydrolipoamide S-succinyltransferase

Dependent Cell Lines

CRISPR: 197/625

RNAi: 93/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (1.0e-21)
2. Solid (5.5e-21)
3. Multiple Myeloma (5.4e-11)
4. Leukemia (3.6e-09)
5. AML (1.2e-06)
6. Central Nervous System (1.8e-06)
7. Glioma (8.7e-06)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (5.4e-17)
2. Solid (6.5e-11)
3. Leukemia (1.2e-08)
4. AML (1.5e-08)
5. Multiple Myeloma (5.0e-08)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotOGDH0.70
PlotSDHB0.53
PlotSDHA0.51
PlotADSL0.50
PlotDLD0.50

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotOGDH0.60
PlotMTHFD10.37
PlotPAICS0.34
PlotDLSTP1-0.33
PlotADSL0.32

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for DLST

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Translocation

Loading table...

Methylation (1kb upstream TSS) (14 75347593-75348593)

CpG Methylation

Select context(s) and press load



  • Official symbol: DLST
  • Full name: dihydrolipoamide S-succinyltransferase
  • Location:
  • Also known as: DLTS
  • Entrez ID: 1743
  • Ensembl ID: ENSG00000119689

Search external sites for DLST