DNAJC19

DnaJ heat shock protein family (Hsp40) member C19

Dependent Cell Lines

CRISPR: 116/625

RNAi: 97/597

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Ovary High Grade Serous (4.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Melanoma (2.2e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotVCAM10.19
PlotNEK110.18
PlotATAD3A0.17
PlotPATJ0.17
PlotRAPGEF5-0.16

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMMP21-0.27
PlotC12orf43-0.23
PlotC12orf43-0.23
PlotGRPEL10.23
PlotSVEP10.22

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (3 180707306-180708306)

CpG Methylation

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  • Official symbol: DNAJC19
  • Full name: DnaJ heat shock protein family (Hsp40) member C19
  • Location:
  • Also known as: Tim14, TIMM14, Pam18
  • Entrez ID: 131118
  • Ensembl ID: ENSG00000205981

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