DOCK5

dedicator of cytokinesis 5

Dependent Cell Lines

CRISPR: 30/625 STRONGLY SELECTIVE

RNAi: 5/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Pancreas (6.4e-18)

RNAi

Dependency Score (DEMETER2)

1. Pancreas (8.6e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotKRAS0.41
PlotCRK0.41
PlotPTPN12-0.40
PlotBCAR10.39
PlotCRKL0.39

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUTP30.36
PlotSNCAIP0.27
PlotCRK0.26
PlotC22orf46-0.26
PlotZNF690.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (8 25041237-25042237)

CpG Methylation

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  • Official symbol: DOCK5
  • Full name: dedicator of cytokinesis 5
  • Location:
  • Also known as: FLJ21034
  • Entrez ID: 80005
  • Ensembl ID: ENSG00000147459

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