DUSP9

dual specificity phosphatase 9

Dependent Cell Lines

CRISPR: 0/582

RNAi: 1/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Colorectal (1.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Colorectal MSI (2.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPRPSAP2-0.26
PlotWTIP0.25
PlotCDK5R20.25
PlotTNRC180.24
PlotDMRTA10.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotZBBX0.31
PlotNKD20.29
PlotODAPH0.28
PlotGDA-0.28
PlotRSPH4A-0.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (23 152906896-152907896)

Methylation (1kb upstream TSS) (23 152911656-152912656)

CpG Methylation

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  • Official symbol: DUSP9
  • Full name: dual specificity phosphatase 9
  • Location:
  • Also known as: MKP4, MKP-4
  • Entrez ID: 1852
  • Ensembl ID: ENSG00000130829

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