EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4

Dependent Cell Lines

CRISPR: 80/625 STRONGLY SELECTIVE

RNAi: 13/708 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotGCN10.66
PlotASNS0.53
PlotATF40.47
PlotGLUL0.34
PlotSLC7A11-0.33

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotATF40.32
PlotASNS0.28
PlotRSPH4A-0.28
PlotCIAO2B-0.26
PlotFAM182B0.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (15 40225324-40226324)

CpG Methylation

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  • Official symbol: EIF2AK4
  • Full name: eukaryotic translation initiation factor 2 alpha kinase 4
  • Location:
  • Also known as: GCN2, KIAA1338
  • Entrez ID: 440275
  • Ensembl ID: ENSG00000128829

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