EIF4G2

eukaryotic translation initiation factor 4 gamma 2

Dependent Cell Lines

CRISPR: 574/625 COMMON ESSENTIAL

RNAi: 218/597

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Pancreas (5.0e-04)

RNAi

Dependency Score (DEMETER2)

1. Breast (3.4e-07)
2. TPBC (3.4e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPRRC2A0.24
PlotVPS180.23
PlotNFIX-0.22
PlotEIF3H0.22
PlotFBXW70.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCCDC1490.27
PlotPRRC2C0.27
PlotEIF3H0.26
PlotKRTAP23-10.25
PlotGRPEL20.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (11 10830582-10831582)

Methylation (1kb upstream TSS) (11 10829543-10830543)

CpG Methylation

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  • Official symbol: EIF4G2
  • Full name: eukaryotic translation initiation factor 4 gamma 2
  • Location:
  • Also known as: p97, DAP5, NAT1
  • Entrez ID: 1982
  • Ensembl ID: ENSG00000110321

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