FBXL18

F-box and leucine rich repeat protein 18

Dependent Cell Lines

CRISPR: 39/625

RNAi: 0/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCYP2W10.26
PlotSLC29A40.24
PlotICE20.24
PlotGPER10.22
PlotGSDME0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotVSTM2B-0.44
PlotPCOLCE-0.40
PlotKCTD190.36
PlotWDFY30.33
PlotZNF131-0.33

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (7 5553431-5554431)

CpG Methylation

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  • Official symbol: FBXL18
  • Full name: F-box and leucine rich repeat protein 18
  • Location:
  • Also known as: Fbl18, FLJ11467
  • Entrez ID: 80028
  • Ensembl ID: ENSG00000155034

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