FDFT1

farnesyl-diphosphate farnesyltransferase 1

Dependent Cell Lines

CRISPR: 57/625 STRONGLY SELECTIVE

RNAi: 0/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. DLBCL (4.2e-05)
2. ERpos (5.6e-05)
3. Colorectal (1.5e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotFDPS0.51
PlotSQLE0.47
PlotUBIAD1-0.33
PlotMSMO10.32
PlotLSS0.32

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTTC260.28
PlotPANX10.28
PlotN4BP2L1-0.28
PlotN4BP2L1-0.28
PlotZG16-0.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (8 11659119-11660119)

Methylation (1kb upstream TSS) (8 11659597-11660597)

Methylation (1kb upstream TSS) (8 11659552-11660552)

Methylation (1kb upstream TSS) (8 11664925-11665925)

Methylation (1kb upstream TSS) (8 11665652-11666652)

CpG Methylation

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  • Official symbol: FDFT1
  • Full name: farnesyl-diphosphate farnesyltransferase 1
  • Location:
  • Also known as:
  • Entrez ID: 2222
  • Ensembl ID: ENSG00000079459

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