FOXA1

forkhead box A1

Dependent Cell Lines

CRISPR: 29/625 STRONGLY SELECTIVE

RNAi: 40/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. ERpos (1.6e-33)
2. Breast (3.2e-19)
3. HER2Amp (2.3e-09)

RNAi

Dependency Score (DEMETER2)

1. Breast (8.2e-32)
2. ERpos (1.6e-19)
3. TPBC (1.4e-14)
4. HER2Amp (2.7e-13)
5. Prostate (3.9e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSPDEF0.42
PlotESR10.38
PlotTRPS10.38
PlotTFAP2C0.31
PlotRBM470.30

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSPDEF0.51
PlotPIK3CA0.40
PlotISCA20.37
PlotSDHB0.35
PlotPTCD30.35

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (14 38064325-38065325)

CpG Methylation

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  • Official symbol: FOXA1
  • Full name: forkhead box A1
  • Location:
  • Also known as: HNF3A
  • Entrez ID: 3169
  • Ensembl ID: ENSG00000129514

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