GOLGA7

golgin A7

Dependent Cell Lines

CRISPR: 12/625

RNAi: 0/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (5.4e-05)
2. Upper Aerodigestive Squamous (1.1e-04)

RNAi

Dependency Score (DEMETER2)

1. Kidney (5.8e-08)
2. Upper Aerodigestive (4.5e-05)
3. Upper Aerodigestive Squamous (4.5e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotZDHHC50.42
PlotNRAS0.30
PlotFAM49B0.27
PlotTAOK10.24
PlotADRB30.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotART10.38
PlotLCT0.38
PlotDNAH9-0.37
PlotWDR380.37
PlotFMR1NB0.33

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (8 41347080-41348080)

Methylation (1kb upstream TSS) (8 41347172-41348172)

Methylation (1kb upstream TSS) (8 41346914-41347914)

CpG Methylation

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  • Official symbol: GOLGA7
  • Full name: golgin A7
  • Location:
  • Also known as: GOLGA3AP1, GCP16, HSPC041, GOLGA7A
  • Entrez ID: 51125
  • Ensembl ID: ENSG00000147533

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