GRK2

G protein-coupled receptor kinase 2

Dependent Cell Lines

CRISPR: 55/625

RNAi: 14/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (2.5e-09)
2. Upper Aerodigestive Squamous (2.8e-09)
3. HER2Amp (2.7e-05)
4. Haematopoietic And Lymphoid (3.7e-05)
5. Solid (4.9e-05)
6. Central Nervous System (4.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Melanoma (3.7e-08)
2. Skin (6.7e-08)
3. ERpos (4.8e-05)
4. Colorectal (4.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCD2480.37
PlotNPAS40.36
PlotPACS10.35
PlotSIPA10.35
PlotBBS10.34

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotFERMT2-0.36
PlotCORO70.33
PlotC7orf310.32
PlotTERC-0.32
PlotPGGT1B0.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (11 67032870-67033870)

CpG Methylation

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  • Official symbol: GRK2
  • Full name: G protein-coupled receptor kinase 2
  • Location:
  • Also known as: ADRBK1, BARK1
  • Entrez ID: 156
  • Ensembl ID: ENSG00000173020

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