HES7

hes family bHLH transcription factor 7

Dependent Cell Lines

CRISPR: 42/625

RNAi: 23/383

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotALOXE30.37
PlotMFSD6L0.35
PlotKRBA20.35
PlotCDRT10.34
PlotWRAP530.33

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRNASE13-0.61
PlotARMH40.41
PlotARMH40.41
PlotCCDC870.38
PlotRIPOR30.37

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (17 8027410-8028410)

CpG Methylation

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  • Official symbol: HES7
  • Full name: hes family bHLH transcription factor 7
  • Location:
  • Also known as: bHLHb37
  • Entrez ID: 84667
  • Ensembl ID: ENSG00000179111

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