HIF3A

hypoxia inducible factor 3 subunit alpha

Dependent Cell Lines

CRISPR: 0/625

RNAi: 7/712

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Urinary Tract (4.8e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTPRX10.21
PlotMED300.21
PlotIGFL20.21
PlotBABAM10.21
PlotGFY0.20

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTMEM2170.28
PlotPROM20.28
PlotCLBA10.26
PlotPLIN20.26
PlotSATB2-AS10.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (19 46800632-46801632)

CpG Methylation

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  • Official symbol: HIF3A
  • Full name: hypoxia inducible factor 3 subunit alpha
  • Location:
  • Also known as: MOP7, IPAS, PASD7, bHLHe17
  • Entrez ID: 64344
  • Ensembl ID: ENSG00000124440

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