HNF1A

HNF1 homeobox A

Dependent Cell Lines

CRISPR: 23/625 STRONGLY SELECTIVE

RNAi: 4/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Liver (1.1e-06)
2. Gastric Adenocarcinoma (1.5e-04)

RNAi

Dependency Score (DEMETER2)

1. Colorectal (8.3e-06)
2. Neuroblastoma (9.4e-05)
3. Peripheral Nervous System (9.4e-05)
4. Haematopoietic And Lymphoid (2.8e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotHNF4A0.33
PlotPCBD10.27
PlotTCF7L20.22
PlotCDC42-0.20
PlotMAP1B-0.20

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotGXYLT1-0.33
PlotTTBK1-0.29
PlotHOXB130.28
PlotGPRC5B0.28
PlotCBLN20.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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  • Official symbol: HNF1A
  • Full name: HNF1 homeobox A
  • Location:
  • Also known as: LFB1, MODY3, TCF1, HNF1
  • Entrez ID: 6927
  • Ensembl ID: ENSG00000135100

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