HSPE1

heat shock protein family E (Hsp10) member 1

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 702/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (4.5e-08)
2. Solid (5.8e-08)
3. Leukemia (3.1e-07)
4. AML (4.0e-04)

RNAi

Dependency Score (DEMETER2)

1. Kidney (2.7e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRAN0.61
PlotRPL370.55
PlotDUX40.54
PlotBUB30.51
PlotRPS130.49

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotHSPD10.49
PlotOR2T110.38
PlotZBTB380.35
PlotIL1A0.31
PlotRPL18A-0.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (2 198363720-198364720)

CpG Methylation

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  • Official symbol: HSPE1
  • Full name: heat shock protein family E (Hsp10) member 1
  • Location:
  • Also known as: CPN10, HSP10, EPF, GroES
  • Entrez ID: 3336
  • Ensembl ID: ENSG00000115541

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