IL1RL1

interleukin 1 receptor like 1

Dependent Cell Lines

CRISPR: 0/625

RNAi: 10/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Central Nervous System (2.0e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotMGAT4A0.35
PlotBCL2L110.30
PlotCNGA30.29
PlotABCB110.28
PlotZC3H60.27

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotN4BP2L10.39
PlotN4BP2L10.39
PlotTRIM670.34
PlotTMA70.32
PlotMRPS18B-0.30

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: IL1RL1
  • Full name: interleukin 1 receptor like 1
  • Location:
  • Also known as: IL33R, T1, FIT-1, DER4, ST2V, ST2L, ST2
  • Entrez ID: 9173
  • Ensembl ID: ENSG00000115602

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