IMPDH2

inosine monophosphate dehydrogenase 2

Dependent Cell Lines

CRISPR: 384/625 COMMON ESSENTIAL

RNAi: 26/712

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Central Nervous System (8.1e-07)
2. Glioma (3.1e-06)
3. Pancreas (3.1e-05)
4. Bone (7.2e-05)
5. Lung Adenocarcinoma (1.2e-04)
6. Lung (1.3e-04)
7. Lung NSC (3.5e-04)

RNAi

Dependency Score (DEMETER2)

1. Leukemia (8.3e-05)
2. Central Nervous System (3.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotGMPS0.62
PlotADSL0.54
PlotPAICS0.53
PlotPPAT0.51
PlotGART0.50

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotADSL0.28
PlotC12orf430.26
PlotC12orf430.26
PlotRNASE130.25
PlotSH3D19-0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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  • Official symbol: IMPDH2
  • Full name: inosine monophosphate dehydrogenase 2
  • Location:
  • Also known as:
  • Entrez ID: 3615
  • Ensembl ID: ENSG00000178035

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