ITGAV

integrin subunit alpha V

Dependent Cell Lines

CRISPR: 303/625

RNAi: 124/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (2.7e-10)
2. Upper Aerodigestive Squamous (1.0e-09)
3. Haematopoietic And Lymphoid (8.0e-08)
4. Solid (2.1e-07)
5. Esophagus (2.8e-05)
6. Kidney (4.8e-05)
7. Esophagus Squamous (4.9e-05)
8. Glioma (4.2e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (5.7e-13)
2. Solid (7.5e-10)
3. Leukemia (3.7e-09)
4. Kidney (2.0e-07)
5. AML (1.3e-06)
6. Melanoma (3.4e-05)
7. Skin (1.5e-04)
8. Esophagus (1.6e-04)
9. Esophagus Squamous (2.4e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotITGB50.69
PlotFERMT20.64
PlotPTK20.63
PlotELMO20.57
PlotVCL0.49

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotFERMT20.61
PlotTLN10.58
PlotITGB50.55
PlotTAOK1-0.51
PlotRAPGEF10.47

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (2 187453789-187454789)

CpG Methylation

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  • Official symbol: ITGAV
  • Full name: integrin subunit alpha V
  • Location:
  • Also known as: VTNR, MSK8, VNRA, CD51
  • Entrez ID: 3685
  • Ensembl ID: ENSG00000138448

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