ITPK1

inositol-tetrakisphosphate 1-kinase

Dependent Cell Lines

CRISPR: 57/625 STRONGLY SELECTIVE

RNAi: 1/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (1.7e-20)
2. Solid (9.7e-20)
3. Multiple Myeloma (1.0e-17)
4. Leukemia (2.1e-06)
5. AML (5.7e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotIPPK0.58
PlotIPMK0.56
PlotNAMPT0.42
PlotPPCDC0.42
PlotADSL0.39

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPI150.51
PlotTHG1L0.47
PlotMPV17L20.46
PlotTMEM2170.44
PlotSCAMP40.43

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (14 93582264-93583264)

Methylation (1kb upstream TSS) (14 93503319-93504319)

CpG Methylation

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  • Official symbol: ITPK1
  • Full name: inositol-tetrakisphosphate 1-kinase
  • Location:
  • Also known as:
  • Entrez ID: 3705
  • Ensembl ID: ENSG00000100605

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