KIAA0586

KIAA0586

Dependent Cell Lines

CRISPR: 4/625

RNAi: 2/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. ERpos (6.6e-08)
2. Breast (3.0e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNSDHL0.35
PlotIL330.34
PlotMMP270.32
PlotCCDC1980.26
PlotVCPKMT0.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRAB6C-AS10.31
PlotLRFN30.30
PlotTRIL0.29
PlotLZTS20.29
PlotF100.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (14 58893102-58894102)

CpG Methylation

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  • Official symbol: KIAA0586
  • Full name: KIAA0586
  • Location:
  • Also known as: Talpid3, JBTS23
  • Entrez ID: 9786
  • Ensembl ID: ENSG00000100578

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